Prepare your answer in advance. Write it, edit it, and make sure it would be OK to say what you wrote.
Be specific and tell about yourself in relation to the position you are applying for. Tell clearly what skills you have. Focus on those skills that are required and explain why you were interested in that job.And NEVER TALK TOO MUCH. Nobody wants to employ a 'chatterbox'.
You will find more ESL job interview questions with provided answers here...